Sustained release matrix system using hydroxyethyl cellulose and

Details Sustained release matrix system using hydroxyethyl cellulose and Sustained release matrix system using hydroxyethyl cellulose and

1993-11-22

1995-09-19

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424469, 424480, 424484, 424488, 424494, 514963, 514964, 514965, A61K 922

Patent

active

054514096

ABSTRACT:
The present invention is directed to a novel sustained release matrix and oral dosage form comprising a homogeneous matrix formed from a wet granulation containing an effective amount of a medicament and a polymer blend of hydroxypropyl cellulose and hydroxyethyl cellulose. The present invention also discloses a novel process for making a sustained release oral dosage form comprising wet granulating a medicament with a polymer blend of hydroxypropyl cellulose and hydroxyethyl cellulose to form a homogeneous matrix, wherein the polymer blend is provided in an amount effective to control the release of said medicament, then forming the homogenous matrix into a solid oral dosage form.

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