Sustained release matrix

Details Sustained release matrix Sustained release matrix

1989-01-19

1990-11-06

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424469, 424470, 424473, 424479, 424480, 424482, A61K 922, A61K 936

Patent

active

049685082

ABSTRACT:
This invention provides a matrix composition for sustained drug delivery which is comprised of an active agent, a hydrophilic polymer and an enteric polymer. The enteric polymer is impermeable to gastric fluids and aids in retarding drug release in regions of low pH, thus allowing lower levels of hydrophilic polymer to be employed. At the pH range of intestinal fluids, this polymer will dissolve and thereby increase the permeability of the dosage form. This approach is useful in sustaining the release of numerous active agents whose solubility declines as the pH is increased, a characteristic of weakly basic drugs. By responding to changes in physiological pH, these sustained release dosage forms have acceptable performance, in spite of variability in the gastrointestinal transit times of the formulation.

REFERENCES:
patent: 3065143 (1960-04-01), Christenson et al.
patent: 3458622 (1969-07-01), Hill
patent: 4252786 (1981-02-01), Weiss et al.
patent: 4309405 (1982-01-01), Gulley et al.
patent: 4389393 (1983-06-01), Schor et al.
patent: 4520009 (1985-05-01), Dunn
patent: 4521401 (1985-06-01), Dunn
patent: 4521402 (1985-06-01), Dunn
patent: 4522804 (1985-06-01), Dunn
patent: 4800084 (1989-01-01), Zerbe
Remington's Pharmaceutical Sciences, Mack Publishing Company, 16th Edition (1980).
Chemical Abstracts 99:110763C.

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