Sustained-release liposomal anesthetic compositions

Details Sustained-release liposomal anesthetic compositions Sustained-release liposomal anesthetic compositions

1998-09-18

2000-04-04

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

264 41, 264 43, A61K 9127

Patent

active

060458240

ABSTRACT:
The invention provides a method for obtaining local anesthetics encapsulated in liposomes, such as multivesicular liposomes, with high encapsulation efficiency and slow release in vivo. When the encapsulated anesthetic is administered as a single intracutaneous dose, the duration of anesthesia and half-life of the drug at the local injection site is increased as compared to injection of unencapsulated anesthetic. The maximum tolerated dose of the encapsulated anesthetic is also markedly increased in the liposomal formulation over injection of unencapsulated anesthetic. These results show that the liposomal formulation of local anesthetic is usefuil for sustained local infiltration and nerve block anesthesia.

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patent: 5049392 (1991-09-01), Weiner
patent: 5244678 (1993-09-01), Legros
Kim T. et al. Extended-release formulations of morphine for subcutaneous administrtion. Cancer Chemother Pharmacol. 1993, vol. 33, pp. 187-190.

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