Sustained release implant and method for preparing same

Details Sustained release implant and method for preparing same Sustained release implant and method for preparing same

1986-10-10

1988-08-02

Lusignan, Michael R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424475, 427 3, A61K 900, A61K 1500, A61K 2100, A61K 922

Patent

active

047612894

ABSTRACT:
A mixture comprising a dispersion of a water-diffusible solid in a solution of a non-aqueous solvent and a substantially water-insoluble polymer is formed. The non-aqueous solvent is removed from the mixture to substantially dry the mixture, and the substantially dry mixture is comminuted to form particles. A plurality of the particles are formed under pressure to produce a pellet suitable for use as a sustained release implant device.

REFERENCES:
patent: 3923939 (1975-12-01), Baker et al.
patent: 4052505 (1977-10-01), Higuchi et al.
patent: 4164560 (1979-08-01), Folkman et al.
patent: 4326525 (1982-04-01), Swanson et al.
patent: 4563489 (1986-01-01), Urist
patent: 4610870 (1986-09-01), Jain et al.
W. D. Rhine, et al., J. of Pharmaceutical Sciences, vol. 69, No. 3, pp. 265-270 (Mar. 1980).

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