Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1998-12-08
2000-10-24
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424488, 514777, 514778, 514779, 514780, 514781, 514964, 514965, A61K 914, A61K 922, A61K 954
Patent
active
06136343&
ABSTRACT:
A sustained release pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, an optional cationic cross-linking agent, and a medicament having moderate to poor solubility is disclosed. In certain embodiments, the sustained release excipient is granulated with a solution or suspension of a hydrophobic polymer in an amount effective to slow the hydration of the gelling agent when the formulation is exposed to an environmental fluid. In another embodiment, the tablet is coated with a hydrophobic polymer.
REFERENCES:
patent: 3485847 (1969-12-01), Bossert et al.
patent: 3784684 (1974-01-01), Bossert et al.
patent: 4191772 (1980-03-01), Woog et al.
patent: 4346709 (1982-08-01), Schmitt
patent: 4412986 (1983-11-01), Kawata et al.
patent: 4562069 (1985-12-01), Hegasy et al.
patent: 4665081 (1987-05-01), Doi et al.
patent: 4673564 (1987-06-01), Kawata et al.
patent: 4696815 (1987-09-01), Schepky et al.
patent: 4764382 (1988-08-01), Kydonieus et al.
patent: 4765989 (1988-08-01), Wong et al.
patent: 4765990 (1988-08-01), Sugimoto et al.
patent: 4792448 (1988-12-01), Ranade
patent: 4792450 (1988-12-01), Kydonieus et al.
patent: 4792452 (1988-12-01), Howard et al.
patent: 4803076 (1989-02-01), Ranade
patent: 4803081 (1989-02-01), Falk et al.
patent: 4808413 (1989-02-01), Joshi et al.
patent: 4851229 (1989-07-01), Magruder et al.
patent: 4867985 (1989-09-01), Heafield et al.
patent: 4880623 (1989-11-01), Piergiogio
patent: 4889723 (1989-12-01), Kim et al.
patent: 4892741 (1990-01-01), Ohm et al.
patent: 4894235 (1990-01-01), Kohne et al.
patent: 4904699 (1990-02-01), Bauer
patent: 4940587 (1990-07-01), Jenkins et al.
patent: 4942040 (1990-07-01), Ragnarsson et al.
patent: 4973469 (1990-11-01), Mulligan et al.
patent: 4983593 (1991-01-01), Miyajima et al.
patent: 4994276 (1991-02-01), Baichwal et al.
patent: 5007790 (1991-04-01), Shell
patent: 5015479 (1991-05-01), Mulligan et al.
patent: 5019397 (1991-05-01), Wong et al.
patent: 5024843 (1991-06-01), Kuczynski et al.
patent: 5051263 (1991-09-01), Barry et al.
patent: 5071642 (1991-12-01), Lahr et al.
patent: 5091190 (1992-02-01), Kuczynski et al.
patent: 5096714 (1992-03-01), Kuhrts
patent: 5100669 (1992-03-01), Hyon et al.
patent: 5108757 (1992-04-01), Erdos et al.
patent: 5110602 (1992-05-01), Kim et al.
patent: 5128142 (1992-07-01), Mulligan et al.
patent: 5128143 (1992-07-01), Baichwal et al.
patent: 5132116 (1992-07-01), Soumac et al.
patent: 5133974 (1992-07-01), Paradissis et al.
patent: 5135757 (1992-08-01), Baichwal et al.
patent: 5145683 (1992-09-01), Rhodes
patent: 5160734 (1992-11-01), Ganesan et al.
patent: 5169638 (1992-12-01), Dennis et al.
patent: 5169639 (1992-12-01), Baichwal
patent: 5211957 (1993-05-01), Hagemann et al.
patent: 5215758 (1993-06-01), Krishnamurthy
patent: 5264446 (1993-11-01), Hegasy et al.
patent: 5264459 (1993-11-01), Chelmick-Schorr et al.
patent: 5273760 (1993-12-01), Oshlack et al.
patent: 5286493 (1994-02-01), Oshlack et al.
patent: 5288500 (1994-02-01), Ibsen
patent: 5292534 (1994-03-01), Valentine et al.
patent: 5356467 (1994-10-01), Oshlack et al.
patent: 5415871 (1995-05-01), Pankhania et al.
patent: 5439687 (1995-08-01), Compassi
patent: 5455046 (1995-10-01), Baichwal
patent: 5472711 (1995-12-01), Baichwal
patent: 5476654 (1995-12-01), Conte et al.
patent: 5478574 (1995-12-01), Baichwal et al.
patent: 5512297 (1996-04-01), Baichwal
patent: 5518730 (1996-05-01), Fuisz
patent: 5543099 (1996-08-01), Zhang et al.
patent: 5554387 (1996-09-01), Baichwal
patent: 5662933 (1997-09-01), Baichwal et al.
patent: 5667801 (1997-09-01), Baichwal
patent: 5670168 (1997-09-01), Baichwal
patent: 5773025 (1998-06-01), Baichwal
patent: 5846563 (1998-12-01), Baichwal
Chemical Abstracts, vol. 104 (1986 Abstract 174662y.
Chemical Abstracts, vol. 99 (1983) Abstract 128360d.
Chemical Abstracts, vol. 92 (1980) Abstract 135278s.
Chemical Abstracts, vol. 92 (1980) Abstract 82429h.
Chemical Abstracts, vol. 77 (1972) Abstract 39130g.
Chemical Abstracts, vol. 70 (1969) Abstract 17133p.
Chemical Abstracts, vol. 98 (1983) Abstract 221832y.
Alderman, D.A., "A Review of Cellulose Ethers in Hydrophilic Matrices for Oral Controlled-Release Dosage Forms," Int. J. Pharm. Tech. & Prod. Mfg., vol. 5, pp. 1-9 (1984).
Haynes, R. Brian, M.D., et al., "Manipulation of the therapeutic regimen to improve compliance: Conceptions and misconceptions," Clinical Pharmacology and Therapeutics, vol. 22, No. 2, (Aug. 1977).
English translation of Japanese Patent Laid-Open-To-Public, publication No. 8/1986, publication date Jan. 6, 1986, Japanese Patent Application No. 118,789/1984; Japanese Patent Application date: Jun. 9, 1984.
Techniques of Solubilization of Drugs, edited by Samual H. Yalkowsky, The Upjohn Company, pub. Marcel Dekker, Inc., New York and Basel, pp. 308-315 (1981).
"Crystallization and Granulation," Remington's Practice of Pharmacy, 9.sup.th Ed. Chapter XXVII, pp. 208-211, 1950.
Sugimoto, I., et al., "Dissolution and Absorption of Nifedipine-Polyvinylpyrrolidone Coprecipitate", Drug Development and Industrial Pharmacy, vol. 6, No. 2, pp. 137-161 (1980).
Kleinblosem, M., et al., Nifedipine: Kinetics and dynamics in health subjects, Clin. Pharmacol. Ther., Vo. 35, No. 6, pp. 742-749 (1984).
Ramasch, K., et al., "Pharmacokinetics and Metabolism of Nifediphine", Hypertension Supplement II, Vo. 5, No. 4, Jul.-Aug. 18-24 (1983).
The Merck Index, pp. 848-849, 9.sup.th Ed. (1976).
D.O.M. Craig, "Polyethyelene Glycols and Drug Release", Drug Development and Industrial Pharmacy, 16(17), pp. 2501-2526 (1990).
Ritschel, Angewandte Blopharmazie, pp. 293-302 (1973) with English Translation.
Edward Mendell Co. Inc.
Nutter Nathan M.
LandOfFree
Sustained release heterodisperse hydrogel systems for insoluble does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sustained release heterodisperse hydrogel systems for insoluble , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sustained release heterodisperse hydrogel systems for insoluble will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1960739