Sustained release heterodisperse hydrogel systems for insoluble

Details Sustained release heterodisperse hydrogel systems for insoluble Sustained release heterodisperse hydrogel systems for insoluble

1995-05-22

1996-09-10

Nutter, Nathan M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

514964, 524 55, A61K 914

Patent

active

055543871

ABSTRACT:
A sustained release pharmaceutical formulation includes a sustained release excipient including a gelling agent, an inert pharmaceutical diluent, an optional cationic cross-linking agent, and a medicament having moderate to poor solubility is disclosed. In certain embodiments, the sustained release excipient is granulated with a solution or suspension of a hydrophobic polymer in an amount effective to slow the hydration of the gelling agent when the formulation is exposed to an environmental fluid. In another embodiment, the tablet is coated with a hydrophobic polymer.

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