Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1998-06-11
2000-02-29
Spear, James M.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424470, 424486, 5147723, 514781, 514785, 514951, 514952, A61K 914, A61K 916
Patent
active
060306440
ABSTRACT:
This invention relates to sustained-release granular preparations obtained by wet-granulating an aqueous suspension, which comprises a medicinal ingredient, a fine particulate polymer having an average particle size not greater than 50 .mu.m and a plasticizer, into granules and treating said granules at a temperature not less than the lower one of a minimum film-forming temperature and glass transition temperature of a mixture of said polymer and said plasticizer. This invention is also concerned with a process for the production of the sustained-release granular preparations. According to the present invention, granular preparations having an excellent sustained-release property and a high safety to the human body can be easily produced in a simple manner.
REFERENCES:
patent: 4330338 (1982-05-01), Banker
patent: 4702918 (1987-10-01), Ushimaru et al.
American Pharm. Assoc./Pharm. Society of Great Britain: Handbook of Pharmaceutical Excipients, pp. 134-137 & 289-293, 1986, "Hydroxypropyl Cellulose" and "Starch".
Kojima Masazumi
Nakagami Hiroaki
Sagasaki Shinji
Daiichi Pharmaceutical Co. Ltd.
Spear James M.
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