Sustained-release granular pharmaceutical preparations

Details Sustained-release granular pharmaceutical preparations Sustained-release granular pharmaceutical preparations

1988-04-18

1990-01-09

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424469, 424470, 424472, 424488, A61K 922, A61K 926

Patent

active

048927384

ABSTRACT:
A favorable sustained-releasing property is given to granular preparations by incorporating therein at least one C.sub.16 -C.sub.18 saturated fatty acid and/or metal salts thereof at a rate of 10-50% of the total weight of the dosage form. The disclosed dosage form releases the active ingredient both in a low pH region of the stomach and in a high pH region of the intestine at an appropriate rate.

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McCallister et al, "Diffuse Reflectance . . . ," J. Pharm. Sci., vol. 59, No. 9, pp. 1287-1289 (1970).
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Aellig et al, Eur. J. Clin. Pharmacol., (1981), 20 [3], 179-183, A Pharmacodynamic and Pharmacokinetic Comparison of Pindolol 20 MG Retard and a Conventional Tablet, abstr. in Chem. Abstr. 95:175720Y (1981).

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