Sustained release formulations of water soluble peptides

Details Sustained release formulations of water soluble peptides Sustained release formulations of water soluble peptides

1995-06-06

1997-06-17

Webman, Edward J.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424486, 424426, A61K 914

Patent

active

056394802

ABSTRACT:
The invention discloses microparticles comprising a polypeptide, preferably somatostatin or an analog or derivative thereof, more preferably octreotide, in a polymeric matrix, preferably poly(lactide-co-glycolide)glucose. The invention also discloses sustained release formulations containing said microparticles and the use of said formulations in treating acromegaly and breast cancer.

REFERENCES:
patent: 4650787 (1987-03-01), Schally et al.
patent: 4675189 (1987-06-01), Kent et al.
patent: 4759577 (1988-07-01), Schally et al.
patent: 4767628 (1988-08-01), Hutchinson
patent: 4853226 (1989-08-01), Machida et al.
patent: 4859763 (1989-08-01), Takayanagi et al.
patent: 4863736 (1989-09-01), Azain et al.
Mason-Garcia, Proc. National Acad. Science, vol. 85, pp. 5688-5692 (1988).
Maulding, Journal of Controlled release, vol. 6, pp. 167-176 (1987).

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