Sustained-release formulations for treating CNS-mediated...

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills

Reexamination Certificate

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Details

C424S464000, C424S472000, C424S476000, C424S480000

Reexamination Certificate

active

09691237

ABSTRACT:
Sustained-release compositions for delivering therapeutic concentrations of isovaleramide, isovaleric acid, and certain structurally related compounds are provided for the treatment for a variety of pathological conditions, including epilepsy and spasticity, which are ameliorated by effecting a modulation of CNS activity. The ability of the compositions to sustain relatively constant levels of the drug at a therapeutic dose in the serum for extended periods of time enables a once or twice daily administration schedule.

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Chemical Abstract, vol. 83, No. 14, Oct. 6, 1975, T.A. Grosovyi et al. “Development of an Optimum Intestine Soluble Film-Forming Composition from Cellulose Acetate Phthalate for Tablet Coating in a Fluidized Bed”.
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