Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Reexamination Certificate
2008-05-20
2008-05-20
Tran, S. (Department: 1618)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
C424S457000, C424S458000, C424S459000
Reexamination Certificate
active
07374781
ABSTRACT:
A sustained release formulation as a unit dose contains 100 mg-1000 mg of Acetaminophen and 15 mg-150 mg of tramadol hydrochloride, which comprises of 1) an immediate release portion comprising of 25%-75% of the total effective amount of drug in the dosage form and 2) a sustained release portion comprising of a) 25%-75% of the total effective amount of drugs in the dosage form; b) 6%-50% of gelling polymers of the total formulation, and c) optionally an enteric coating at a level of 5%-40% of the total formulation. The set forth formulation dissolves 25%-60% of the total drug in the first hour, 50%-90% of the total drug in the first four hours and not less than 80% of the total drug in the first 12 hours using USP dissolution method II at 50 rpm.
REFERENCES:
patent: 5336691 (1994-08-01), Raffa et al.
patent: 6375957 (2002-04-01), Kaiko et al.
patent: 6491949 (2002-12-01), Faour et al.
Wang Jin
Zhang Shuyi
Fuchs Joseph A.
Rockey Depke & Lyons, LLC
Tran S.
LandOfFree
Sustained release formulations containing acetaminophen and... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sustained release formulations containing acetaminophen and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sustained release formulations containing acetaminophen and... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2767171