Sustained release formulations

Details Sustained release formulations Sustained release formulations

1990-07-27

1993-02-23

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424441, 424472, 424474, A61K 4700

Patent

active

051888360

ABSTRACT:
Semi-enteric controlled release formulations are comprised of a biological active agent such as an antibiotic that is blended with a water-soluble bulking agent, the mix then coated onto an inert core. The coated active core is further coated with a mixture comprised of an acrylic copolymer, bulking agent and pH dependent food acid. These different coating components possess different solubility characteristics which result in a gradual release of the active in both the stomach and small intestine that provides an increased bioavailability of the active drug.

REFERENCES:
patent: 3993072 (1976-11-01), Zaffaroni
patent: 4459279 (1984-07-01), Stricher et al.
patent: 4954350 (1990-09-01), Jones et al.

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