Sustained release formulation of animal growth hormone and proce

Details Sustained release formulation of animal growth hormone and proce Sustained release formulation of animal growth hormone and proce

1996-11-13

1998-04-28

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424457, 424458, 424468, 424497, A61K 914

Patent

active

057441634

ABSTRACT:
The present invention relates to a sustained-release formulation of an animal growth hormone and a process for preparation thereof, comprising a step to produce solid pellets by mixing an animal growth hormone and an excipient in accordance with a direct tabletting method and a step to coat the pellets with a film comprising a biodegradable polymer and a poloxamer. The thus obtained formulation has small initial drug release, and shows a continuous and uniform effect when administered. Further, the formulation of the present invention may be produced economically in a large scale.

REFERENCES:
patent: 5317079 (1994-05-01), Domb et al.
patent: 5482927 (1996-01-01), Maniar et al.

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