Sustained release formulation containing three different types o

Details Sustained release formulation containing three different types o Sustained release formulation containing three different types o

1995-03-01

1997-12-09

Spear, James M.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424469, 424486, 424487, 424488, 5147723, 514779, 514781, 514960, 514961, A61K 922

Patent

active

056957815

ABSTRACT:
Verapamil depot drug formulations include the pharmaceutical itself and a three component release rate controlling matrix composition. The three components of the matrix composition are (1) an alginate component, such as sodium alginate, (2) an enteric polymer component, such as methacrylic acid copolymer, and (3) a pH independent gelling polymer, such as hydroxypropyl methylcellulose or polyethyleneoxide. The drug release rate can be adjusted by changing the amount of one or more of these components of the composition.

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