Sustained release formulation containing captopril and method

Details Sustained release formulation containing captopril and method Sustained release formulation containing captopril and method

1993-10-13

1995-07-18

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

424468, 424502, A61K 922

Patent

active

054339510

ABSTRACT:
A sustained release captopril formulation is provided which is in the form of a capsule containing captopril in a semi-solid matrix of at least one fatty acid glyceride and/or polyethylene glycol ester. A method of preparing such a formulation is also provided.

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C. Brossard et al, "Modelling of Theophylline Compounds Release from Hard Gelatin Capsules Containing Gelucire Matrix Granules", Drug Dev. Ind. Pharm., 17(10) 1267-1277 (1991).
V. Ratsimbazafy et al, "Les Gelucire et al ralentissement de la liberation des principes actifs", S.T.P. Pharma Prat., 1(4), 335-349 (1991).

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