Sustained release drug-resin complexes

Details Sustained release drug-resin complexes Sustained release drug-resin complexes

1988-11-02

1991-02-26

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 78, 424486, 424484, 424483, 424490, 514964, 514781, A61K 3174, A61K 914, A61K 952

Patent

active

049960474

ABSTRACT:
Disclosed are oral pharmaceutical preparations which comprise a pharmacologically active drug bound to small particles of an ion-exchange resin to provide a drug-resin complex having a drug content above a specified value. The drug-resin complex is subsequently coated with a water-permeable diffusion barrier coating that is insoluble in gastrointestinal fluids thereby providing a controllable sustained release of drug under conditions encountered in the gastrointestinal tract.

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Journal of Pharmaceutical Science, vol. 60, pp. 1523-1527.

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