Sustained release drug dosage forms containing hydroxypropylmeth

Details Sustained release drug dosage forms containing hydroxypropylmeth Sustained release drug dosage forms containing hydroxypropylmeth

1988-12-15

1991-01-08

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424433, 424434, 424435, 424436, 424464, A61K 920

Patent

active

049833987

ABSTRACT:
A therapeutically active solid unit dosage form comprising a carrier base material combined with a therapeutically active medicament and shaped and compressed to a solid unit dosage form having a controlled and sustained release pattern upon administration, the carrier base material comprising a mixture of one or more nonionic cellulose ethers and an alkali metal carboxylate, wherein at least one of the cellulose ethers is hydroxypropylmethylcellulose having a number average molecular weight of at least 50,000.

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L. C. Feely et al., "Influence of Surfactants on Drug Release from Hydroxypropyl Methyl Cellulose Matrices", Chemical Abstracts, 108, p. 437 (1988).
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