Sustained-release drug delivery system

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills

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424457, 424459, 424461, 424462, 424469, 424476, 424487, 424489, 424490, 424493, 424497, 424502, 514 54, 514 60, 514317, 514646, 514647, 514965, A61K 922, A61K 924, A61K 926

Patent

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054846080

ABSTRACT:
A sustained-release pharmaceutical composition comprising a highly soluble pharmaceutical agent, such as selegiline, in a pharmaceutical carrier comprising a hydrophilic polymer dispersed in a hydrophobic matrix. A hydrophilic microenvironment is created in a hydrophobic matrix by incorporating hydrophilic polymers within a hydrophobic matrix. Optionally, a binder, preferably a polyhydroxylated compound, ca also be added.

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Physician's Desk Reference (1995), pp. 2430-2432.

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