Sustained release dosage form

Details Sustained release dosage form Sustained release dosage form

1990-02-08

1992-06-30

Pace, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424422, 424424, 424489, 424490, 514885, 514922, A61K 950, A61K 952, A61K 954, A61K 958

Patent

active

051261472

ABSTRACT:
A multiphasic sustained release injectable delivery system is provided, as well as a method for treating humans and other mammals with that multiphasic sustained release system. The multiphasic sustained release system comprises prolonged, controlled delivery of microencapsulated macromolecular bioactive agent of biological origin comprising the bioactive agent encapsulated in microcapsules of bioerodible encapsulating polymer, which permits a sustained, multiphasic release of said bioactive agent, including (i) a first portion of said bioactive agent that upon injection is capable of being released from said microcapsules of bioerodible encapsulating polymer in a manner whereby only a relatively small amount of said bioactive agent is released during said first phase, whereby initial biological reaction is minimized due to said first portion producing a mild reaction similar to that normally observed with low doses of conventional administration; and (ii) secondary portions of said bioactive agent that provide a substantially higher level of bioactive agent in doses which could provoke a serious reaction in the patient, but for the prior release of said first portion.

REFERENCES:
patent: 3429827 (1969-02-01), Ruus
patent: 3761585 (1973-09-01), Mullan et al.
patent: 3792159 (1974-02-01), Green et al.
patent: 3794630 (1974-02-01), Mullan et al.
patent: 3825525 (1974-07-01), Mullan et al.
patent: 3893993 (1975-07-01), Mullan et al.
patent: 3903067 (1975-09-01), Mullan et al.
patent: 3976071 (1976-08-01), Sadek
patent: 3978203 (1976-08-01), Wise
patent: 4070455 (1978-01-01), Green et al.
patent: 4093709 (1978-06-01), Choi et al.
patent: 4131648 (1978-12-01), Choi et al.
patent: 4140679 (1979-02-01), Malley
patent: 4158705 (1979-06-01), Malley
patent: 4164560 (1979-08-01), Folkman et al.
patent: 4180562 (1979-12-01), Patterson et al.
patent: 4215036 (1980-07-01), Malley
patent: 4222907 (1980-09-01), Katz
patent: 4226853 (1980-10-01), Marsh
patent: 4234569 (1980-11-01), Marsh
patent: 4256732 (1981-03-01), Malley
patent: 4261973 (1981-04-01), Lee et al.
patent: 4269764 (1981-05-01), Patterson et al.
patent: 4338297 (1982-07-01), Michael et al.
patent: 4351337 (1982-09-01), Sidman
patent: 4428932 (1984-01-01), Overell
patent: 4439199 (1984-03-01), Amkraut et al.
patent: 4469677 (1984-09-01), Michael et al.
patent: 4479911 (1984-10-01), Fong
patent: 4526938 (1985-07-01), Churchill et al.
patent: 4609547 (1986-09-01), Garman et al.
patent: 4675189 (1987-06-01), Kent et al.
patent: 4675381 (1987-06-01), Bichon
patent: 4683288 (1987-07-01), Tanaka et al.
patent: 4757128 (1988-07-01), Domb et al.
patent: 4767628 (1988-08-01), Hutchinson
patent: 4774074 (1988-09-01), Snipes
patent: 4781919 (1988-11-01), Liebowitz
patent: 4861627 (1989-08-01), Mathiowitz et al.
patent: 4994279 (1991-02-01), Aoki et al.

Affiliated with

Also associated with

Rating

Sustained release dosage form does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Sustained release dosage form, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sustained release dosage form will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1862533