Sustained release dosage form

Details Sustained release dosage form Sustained release dosage form

1989-02-08

1991-02-05

Cashion, Jr., Merrell C.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424 88, 424 89, 424 91, 424428, 424486, 424496, 424543, A61K 3900, A61K 3935, A61K 3936, A61K 914

Patent

active

049903365

ABSTRACT:
A multiphasic sustained release injectable delivery system is provided, as well as a method for treating humans and other mammals with that multiphasic sustained release system. The multiphasic sustained release system comprises prolonged, controlled delivery of microencapsulated allergen extract comprising allergen extract encapsulated in microcapsules of bioerodible encapsulating polymer, which permits a subtained, multiphasic release of said allergen extract, including (i) a first portion of allergen extract that upon injection is capable of being released from said microcapsules of bioerodible encapsulating polymer in a manner whereby only a relatively small amount of said allergen extract is released during said first phase, whereby initial allergenicity is minimized due to said first portion producing a mild local reaction similar to that normally observed with low doses of conventional allergen administration; and (ii) secondary portions of allergen extract that provide a substantially higher level of allergen extract in doses which could provoke a serious reaction in the patient, but for the prior release of said first portion.

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MEDISORB.TM.: Bioresorbable Polymers (Properties, Uses, Storage and Handling), DuPont Company, date is belived to be Mar. 1989.

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