Sustained release capsule or tablet formulation comprising a pha

Details Sustained release capsule or tablet formulation comprising a pha Sustained release capsule or tablet formulation comprising a pha

1988-09-30

1991-05-14

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Capsules

424 80, 424462, 424463, 424464, 424465, 424468, 424469, 514356, 514965, A61K 920, A61K 3720, A61K 922

Patent

active

050154796

ABSTRACT:
A sustained release capsule or tablet formulation suitable for once-daily administration comprises an adsorbate of a mixture of a pharmaceutically useful dihydropyridine and a polyvinylpyrrolidone having an average-molecular weight greater than 55,000 adsorbed on a cross-linked polyvinylpyrrolidone and blended with a polymer or mixture of polymers which gel in the presence of water, the amount of said polymer or polymers being effective to produce the desired sustained release effect.

REFERENCES:
patent: 3065143 (1962-11-01), Christenson et al.
patent: 4369172 (1983-01-01), Schor et al.
patent: 4389393 (1983-06-01), Schor et al.
patent: 4539199 (1985-09-01), Orban et al.
patent: 4540566 (1985-09-01), Davis et al.
patent: 4562069 (1985-12-01), Hegasy et al.
patent: 4695467 (1987-09-01), Uemura et al.
patent: 4753801 (1988-06-01), Oren et al.

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