Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Specially adapted for ruminant animal
Patent
1993-12-07
1996-10-08
Phelan, D. Gabrielle
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Specially adapted for ruminant animal
604 55, 604135, 6048901, A23K 118
Patent
active
055629156
ABSTRACT:
A sustained release capsule adapted to be inserted into the rumen of a ruminant animal and means for retention of the capsule in the rumen. A sustained release capsule adapted to be inserted into the rumen of a ruminant animal through its oesophagus and retained within the rumen over a prolonged period to continuously deliver a biologically active composition carried in the capsule, comprising an elongated tubular body comprising a tube and an end cap secured to one end thereof for substantially enclosing the biologically active composition, the other end of the capsule being a delivery end, the body having an opening at the delivery end of the capsule for delivery of the composition to the rumen, and a plurality of retention arms attached to or formed integrally with the cap, the arms being adapted to extend outwardly from the cap for retaining the capsule in the rumen, the arms being resilient to enable them to bend from their outwardly extending positions toward the body so that they lie alongside the body allowing the capsule to be inserted through the animal's oesophagus, the resilient arms normally extending from the body at an angle between 75.degree. and 90.degree. with respect to the axis of the tubular body, and for each arm said cap has an external curved surface disposed with respect to the arm so that when the arm is bent toward the body, the arm contacts the curved surface and the curved surface controls the bending of the arm so that the arm does not bend abruptly, said arms being adapted to return to their outwardly extending positions when the capsule reaches the rumen, characterized in that said cap is secured to said one end by means of at least two circumferential beads having at least one sealing ring located therebetween.
REFERENCES:
patent: 4416659 (1983-11-01), Simpson
patent: 4929233 (1990-05-01), Roth
Lowe Lionel B.
McArthur Colin J.
Eli Lilly and Company
Phelan D. Gabrielle
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