Sustained release bolus effective for the prolonged prevention,

Details Sustained release bolus effective for the prolonged prevention, Sustained release bolus effective for the prolonged prevention,

1993-05-25

1994-06-21

Michl, Paul R.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Specially adapted for ruminant animal

424484, 424DIG10, 514450, A61K 3135

Patent

active

053226925

ABSTRACT:
A sustained release bolus composition, containing a prophylactically effective amount of a compound selected from LL-F28249.alpha., 23-(O-methyloxime)-LL-F28249.alpha. and derivatives thereof provides a method for protecting ruminant animals for a prolonged period of time against infestation by nematodes, acarids and endoand ectoparasitic insects, and which over time can also eliminate the initial population of parasites present at treatment. The invention also relates to a method for the systemic control of ectoparasitic insect infestations of ruminant animals by orally administering to said animals a sustained release bolus containing an insecticidally effective amount of LL-F28249.alpha., 23-(O-methyloxime) LL-F-28249.alpha. or derivative thereof, which continuously releases into the rumen of the treated animal a systemically effective amount of LL-F28249.alpha., 23-(O-methyloxime)LL-F28249.alpha. or derivative thereof.

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