Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
1999-03-08
2003-06-10
Dees, Jose G. (Department: 1616)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C424S065000, C424S070100, C512S001000
Reexamination Certificate
active
06576247
ABSTRACT:
FIELD
The present invention relates to a sustained-release aromatic comprising a gradually releasable perfume derivative. The present invention particularly relates to a sustained-release aromatic comprising a gradually releasable perfume derivative which is decomposed by micro-organisms to release an aroma component, and to a method for the detection of micro-organisms by the sustained-release aromatic.
PRIOR ART
Various methods has been used in the prior art to blend perfumes in a sustained-release aromatic composition, such as cosmetics, e.g. hair liquids, hair mousses and antiperspirant agents, room aromatics and drinks and foods. For example, in liquid products use have been made of water-solublilized perfumes obtained by dissolving oily perfumes in a solvent or carrier such as alcohols, propylene glycol, carbitol, etc. Alternatively, oily perfumes have been solubilized or emulsified in liquid or creamy products by the use of a surfactant. In powdery or solid products, these oily perfumes has generally been blended as powder or granule made by means of adsorption, capsulation or coating with the aid of a proper excipient, or as a clathrate compound.
Perfumes added to a sustained-release aromatic composition in the prior art have a problem that they start to be released immediately after applied to, for example, a human body and is quickly lost with the passage of time. In order to prevent such too quick diffusion of aroma, carriers are added. However, this method was insufficient in the effect. The perfumes added as a clathrate compound or a capsulated material are excellent in keeping the perfumes, but not too much excellent to emit aroma. Accordingly, they are not always satisfactory as a perfume-carrying material. Thus, there has been a strong desire for a sustained-release aromatic composition which stably generates aroma to a proper extent over a long time.
In order to solve this problem, there has been proposed an aromatic composition comprising an enzyme or acid and a derivative of a perfume which decomposes by the action of the enzyme or acid to form a perfume (e.g. glycosides or glycerides of a perfume, or amino acid or peptide derivatives of a perfume) (Japanese Patent Application Laid-Open Nos. Hei-4-170961/92, Hei-5-230496/93 and Hei-5-239491193). However, in the aromatic composition comprising an acid, it is necessary to blend the acid at a high concentration in the composition. This, therefore, causes a problem of safety when it is put on the skin.
There has also been proposed an oral composition in which at least one glycoside selected from thymol glycosides, cis-3-hexenol glycosides and methyl salicylate glycosides is added (Japanese Patent Application Laid-Open No. Hei-3-90016/91). When the composition is used, the glycoside is hydrolyzed by the action of glucosidase in saliva to release thymol, cis-3-hexenol or methyl salicylate, respectively, and exhibit flavor.
In addition to the aforesaid glycosides, there are known glycosides of mono-terpenes, such as perillyl alcohol, which are present in natural plants and can be synthesized easily and which exhibit pharmacological activity in cooperation with other components (Japanese Patent Application Laid-Open Nos. Hei-3-287597/91 and Hei-4-300889/92). However, the aforesaid publications do not refer to its aromatic effect.
An agent which gradually releases active components has also been proposed. This is an ester of a polyvalent alcohol having a carboxylic group or an oxyalkylene derivative of a polycarboxylic acid with a hydroxide group-containing active component (Japanese Patent Application Laid-Open No. Hei-3-17025/91). However, because the molecular weight of the polyvalent alcohol or the oxyalkylene derivative is relatively high, a ratio of aromatic components contained as the active component is small. Accordingly, it is unsatisfactory in an extent of aroma. In addition, as the aforesaid agent generates the active components as a result of hydrolysis, it is poor in stability during storage for a long period. This leads to a problem that aroma decreases with the passage of time.
DISCLOSURE OF THE INVENTION
A purpose of the present invention is to provide a sustained-release aromatic which is excellent in keeping aroma and a method for the detection of micro-organism using the same.
The present inventors have made researches to provide a sustained-release aromatic which stably generates aroma to a proper extent over a long time. As a result, we have found that when a perfume derivative selected from glycosides, phosphate ester derivatives, amino acid derivatives and carboxylic acid derivatives of perfume components is put on the skin, the perfume derivative itself releases very weak aroma, but it is decomposed by bacteria usually present on the skin to generate perfume components and the gradual decomposition by bacteria provides stable release of aroma over a long time. It has further been found that it does not happen that aroma decreases quickly with the passage of time by increased decomposition of the perfume derivative with propagation of these bacteria usually present on the skin which are safe for organisms. In addition, it has been found that as yeast also gradually decomposes the aforesaid perfume derivative, aroma is released stably over a long time.
The perfume derivatives contained in the sustained-release aromatic of the invention have no aroma or extremely weak aroma in themselves. Accordingly, it is possible to detect the presence and propagation of micro-organism such as bacteria usually present on the skin or yeast using the sustained-release aromatic of the invention by detecting the released aroma.
The present invention provides a sustained-release aromatic, characterized in that the aromatic comprises at least one perfume derivative as an active component selected from glycosides of perfumes, phosphoric acid ester derivatives of perfumes, amino acid derivatives of perfumes and carboxylic acid derivatives of perfumes, and contains no enzyme or acid which decomposes the perfume derivative, wherein the perfume derivative is decomposed by bacteria usually present on the skin or yeast to release a perfume component to exhibit aroma.
The present invention also provides a method for the detection of micro-organisms, characterized by use of a sustained-release aromatic comprising at least one perfume derivative as an active component selected from glycosides of perfumes, phosphoric acid ester derivatives of perfumes, amino acid derivatives of perfumes and carboxylic acid derivatives of perfumes, wherein the perfume derivative is decomposed by a micro-organism to diffuse aroma which is then detected.
The sustained-release aromatic of the present invention comprises a perfume derivative which is not volatile, or less volatile, compared to a perfume, and a volatile perfume is released gradually by the action of micro-organisms only after it is put into use. Accordingly, the perfume derivative is not decomposed during storage before it is used and, therefore, is excellent in a long time stability. The sustained-release aromatic of the present invention does not contain any enzyme nor acid which decomposes the aforesaid perfume derivative to release the perfume.
Meanwhile, the invention disclosed in Japanese Patent Application Laid-Open No. Hei-4-170961192 provides an aromatic composition which comprises a blended perfume comprising at least each one of top note, middle note and base note which are different from each other in volatility, characterized in that the whole or a partial amount of the at least one perfume is blended, together with an enzyme, in the form of a precursor, e.g. glycosides or glycerides of a perfume, or amino acid or peptide derivatives of a perfume, which converts into the perfume via decomposition by the action of the enzyme. However, in the aromatic composition proposed in the above publication, immediately after the precursor is blended with the enzyme, the precursor decomposes quickly. Accordingly, it has a drawback that aroma becomes weaker with the passage of time
Fujita Akira
Ikemoto Takeshi
Inui Masami and Masayuki
Inui Masayoshi
Iwamoto Minoru
Dees Jos,e G.
Inui Masami and Masayuki
Kanebo Ltd. and T. Hasegawa Co. Ltd.
Lamm Marina
Townsend and Townsend / and Crew LLP
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