Drug – bio-affecting and body treating compositions – Lymphokine – Interferon
Patent
1994-08-24
1997-05-13
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Lymphokine
Interferon
424 852, 424 854, 424423, 424468, 514 2, 514 3, 514786, A61K 3802, A61K 3821, A61K 4714
Patent
active
056289936
ABSTRACT:
A parenteral pharmaceutical preparation comprises a matrix containing a physiologically active peptide or protein and a polyglycerol diester of a saturated fatty acid, and the matrix is in a solid form at room temperature. The molecular weight of the physiologically active peptide or protein is 2,000 dalton or more. The saturated fatty acid includes fatty acids having about 16 to 30 carbon atoms such as palmitic acid, stearic acid, etc. The matrix may be in a pillar or granular form. The parenteral pharmaceutical preparation can be used as an injectable solid administered subcutaneously or intramuscularly (for example, a pellet or tablet for implantation), a suppository or the like, and can release the physiologically active peptide or protein sustainedly for a prolonged period of one week or more.
REFERENCES:
patent: 5162057 (1992-11-01), Akiyama et al.
patent: 5189148 (1993-02-01), Akiyama et al.
patent: 5352662 (1994-10-01), Brooks et al.
Aggarwal et al. Human Cytokines, Boston: Blackwell Scientific Publications, 1992, pp. 5-9, 20, 32, 33.
Iga Katsumi
Okada Hiroaki
Yamagata Yutaka
Russel Jeffrey E.
Takeda Chemical Industries Ltd.
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