Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2008-09-23
2008-09-23
Kaushal, Sumesh (Department: 1633)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C424S093100, C424S422000, C424S484000, C424S085100, C435S069100, C435S320100, C435S325000, C435S455000, C514S002600, C514S054000
Reexamination Certificate
active
09442542
ABSTRACT:
Disclosed are particular 3-dimensional structural matrices containing nucleic acids, various fabrication processes and methods for the prolonged release of nucleic acids in various biological environments. The nucleic acid-matrix materials are created such that they maintain a defined space, allowing cellular migration, transfection and proliferation to occur in a controlled manner. The fabrication processes provide for both high incorporation efficiencies and control over the sustained nucleic acid release. The resultant nucleic acid-containing structural matrices are thus particularly useful in in vivo cell transfection and gene expression in the context of gene therapy.
REFERENCES:
patent: 3975350 (1976-08-01), Hudgin et al.
patent: 4871384 (1989-10-01), Kasuga
patent: 4933185 (1990-06-01), Wheatley et al.
patent: 5514378 (1996-05-01), Mikos et al.
patent: 5639473 (1997-06-01), Grinstaff et al.
patent: 5763416 (1998-06-01), Bonadio et al.
patent: 5785965 (1998-07-01), Pratt et al.
patent: 5792751 (1998-08-01), Ledley et al.
patent: 5942496 (1999-08-01), Bonadio et al.
patent: 5965125 (1999-10-01), Mineau-Hanschke
patent: 6033719 (2000-03-01), Keogh
patent: 6143037 (2000-11-01), Goldstein et al.
patent: 6187329 (2001-02-01), Agrawal et al.
patent: 6281256 (2001-08-01), Harris et al.
patent: 6391311 (2002-05-01), Ferrara et al.
patent: 6423085 (2002-07-01), Murayama et al.
patent: 6537567 (2003-03-01), Niklason et al.
patent: 6541022 (2003-04-01), Murphy et al.
patent: 6642363 (2003-11-01), Mooney et al.
patent: 6767928 (2004-07-01), Murphy et al.
patent: 6797738 (2004-09-01), Harris et al.
patent: 0 248 531 (1987-05-01), None
Shapiro et al Biomaterials 18:583-590, 1997.
Fang et al PNAS 03:5753-5758, 1996.
Kawada et al FEBS Letts. 408;43-46, 1997.
Connolly, “Bioelectronic Interfacing: Micro- and Nanofabrication Techniques for Generating Predetermined Molecular Arrays,”Tibtech, 12:123-127, 1994.
James et al., “Small changes in polymer chemistry have a large effect on the bone-implant interface,”Biomaterials, 20:2030-2212, 1999.
Li et al., “In Vitro Calcium Phosphate Formation on a Natural Composite Material, Bamboo,”Biomaterials, 18:389-395, 1997.
Oliveira et al., “Surface modification tailors the characteristics of biomimetic coating nucleated on starch-based polymers,”Journal of Materials Science: Materials in Medicine, 10:827-835, 1999.
Reis et al., “Treatments to induce the nucleation and growth of apatite-like layers on polymeric surface and foams,”Journal of Materials Science: Materials in Medicine, 8:897-905, 1997.
Tanahashi and Matsuda, “Surface Functional Group Dependence on Apatite Formation on Self-Assembled Monolayers in a Simulated Body Fluid,”Journal Biomedical Materials Research, 34:305-315, 1997.
Riessen et al., “Arterial Gene Transfer Using Pure DNA Applied Directly to a Hydrogel-Coated Angioplasty Balloon,”Human Gene Therapy, 4:749-758, 1993.
Gunasekaran et al., “Mineralized Collages as a Substitute for Autograft Bone that can Deliver Bone Morphogenic Protein,”19thAnn. Meeting of the Society for Biomaterials, Apr. 28-May 2, 1993.
Gunasekaran et al., “Role of Mineralized Collagen as an Osteoconductive Biomaterial,”19thAnn. Meeting of the Society for Biomaterials, Apr. 28-May 2, 1993.
Abe, Kokubo and Yamamuro, “Apatite coating on ceramics, metals and polymers utilizing a biological process,”J. Mat. Sci.: Mat. Med., 1:233-238, 1990.
Bradt et al., “Biomimetic mineralization of collagen by combined fibril assembly and calcium phosphate formation,”Chem. Mater., 11:2694-2701, 1999.
Gao, Niklason and Langer, “Surface hydrolysis of poly (glycolic acid) meshes increases the seeding density of vascular smooth muscle cells,”J. Biomed. Mater. Res., 42(3):417-424, 1998.
Li, Bakker and van Blitterswijk, “The bone-bonding polymer polyactive® 80/20 induces hydroxycarbonate apatite formation in vitro,”J. Biomed. Mat. Res., 34:79-86, 1997.
Miyaji et al., “Bonelike apatite coating on organic polymers: Novel nucleation process using sodium silicate solution,”Biomaterials, 20:913-919, 1999.
Murphy, Kohn and Mooney, “Growth of continuous bonelike mineral within porous poly(lactide-co-glycolide) scaffolds in vitro,”J. Biomed. Mater. Res., 50(1):50-58, 2000.
Peters and Mooney, “Growth factor delivery from tissue engineering matrices: Inducing angiogenesis to enhance transplanted cell engraftment,” In:Controlled Drug Delivery: Designing Technologies for the Futute, Park and Mrsny, Eds., Washington, D.C., American Chemical Society, Ch. 16, p. 157-166, 2000.
Shea et al., “DNA delivery from polymer matrices for tissue engineering,”Nature Biotechnology, 17(6):551-554, 1999.
Sheridan et al., “Bioabsorbable polymer scaffolds for tissue engineering capable of sustained growth factor delivery,”Journal of Controlled Release, 64:91-102, 2000.
Taguchi et al., “A study on hydroxyapatite formation on/in the hydroxyl groups-bearing nonionic hydrogels,”J. Biomater. Sci. Polymer Edn., 10(1):19-32, 1999.
Varma et al., “Porous calcium phosphate coating over phosphorylated chitosan film by a biomimetic method,”Biomaterials, 20:879-884, 1999.
Wen et al., “Preparation of calcium phosphate coating on titanium implant materials by simple chemistry,”J. Biomed. Mater. Res., 41:227-236, 1998.
Zhang and Ma, “Porous poly(L-lactic acid)/apatite composites created by biomimetic process,”J. Biomed. Mater. Res., 45:285-293, 1999.
Bonadio Jeffrey
Mooney David J.
Peters Martin C.
Shea Lonnie D.
Kaushal Sumesh
Marshall, Gernstein & Borun LLP
The Regents of the University of Michigan
LandOfFree
Sustained DNA delivery from structural matrices does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Sustained DNA delivery from structural matrices, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Sustained DNA delivery from structural matrices will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3926656