Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1995-08-18
1998-01-06
Phelan, D. Gabrielle
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424450, 6048901, A61K 924
Patent
active
057051917
ABSTRACT:
The present invention is a method for releasing an active agent into a use nvironment, by disposing this active agent within the lumen of a population of tubules, and disposing the tubules into a use environment, either directly or in some matrix such as a paint in contact with the use environment. The tubules have a preselected release profile to provide a preselected release rate curve. The preselected release profile may be achieved by controlling the length or length distribution of the tubules, or by placing degradable endcaps over some or all of the tubules in the population, or by combinations of these methods. The invention is also a population of tubules having a preselected release profile to provide a preselected release rate curve.
REFERENCES:
patent: 4017303 (1977-04-01), Koester
patent: 4720384 (1988-01-01), DiLuccio
patent: 4867917 (1989-09-01), Schnur
patent: 5049382 (1991-09-01), Price
patent: 5290960 (1994-03-01), Singh
patent: 5366881 (1994-11-01), Singh
patent: 5492696 (1996-02-01), Price
Gaber Bruce P.
Price Ronald R.
Rudolph Alan S.
Schnur Joel M.
Selinger Jonathan
Karasek John J.
McDonnell Thomas E.
Phelan D. Gabrielle
The United States of America as represented by the Secretary of
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