Sustained and controlled release of water insoluble polypeptides

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 15, 514 16, 514 17, 514 18, 424409, 424417, 424490, 424491, A61K 3804, A61K 952

Patent

active

057768854

ABSTRACT:
A pharmaceutical composition for the sustained release of a peptide wherein the composition includes a polylactide polymer, a polymer of lactic acid and glycolic acid, or a mixture of such polymers and a therapeutically active peptide in the form of its pamoate, tannate or stearate salt. The composition when placed in an aqueous physiological environment releases the peptide in a continuous manner for a period of at least about one week.

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Chang, "Biodegradable Semipermeable Microcapsules Containing Enzymes, Hormones, Vaccines and Other Biologicals", J. Bioeng. 1 (1976) p. 25.
Langer, "Controlled Release of Macromolecules", Chemtech Feb. 1982 pp. 98-105.
Hutchison et al., "Biodegradable Carriers for the Sustained Release of Polypeptides", TIBTECH Apr. 1987 (vol. 5) pp. 102-106.
Chemical Abstracts, vol. 107, No. 13, Abstract 109765g (1987).

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