Sustained and controlled release of water insoluble polypeptides

Details Sustained and controlled release of water insoluble polypeptides Sustained and controlled release of water insoluble polypeptides

1988-09-20

1993-03-09

Griffin, Ronald W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 3, 514 12, 514 13, 514 14, 514 15, 514 16, 530303, 530304, A61K 3726, C07K 740

Patent

active

051927411

ABSTRACT:
There is disclosed a pharaceutical composition for sustained and controlled release of drug over an extended period of time comprising a polylactide, a copolymer of lactic and glycolic acid, a mixture of such polymers and a water-insoluble peptide which, when placed in an aqueous physiologically-type environment releases the peptide in continuous manner for a period of at least one week, and with an initial release for the first twenty-four hours of not more than 30% of the total amount released. There is thus provided the control of the release pattern and in general a decrease of the initial burst effect.

REFERENCES:
patent: 4010125 (1977-03-01), Schally et al.
patent: 4622244 (1986-11-01), Lapka et al.
patent: 4675189 (1987-06-01), Kent et al.
patent: 4767628 (1988-08-01), Hutchison
Chang, "Biodegradable Semipermeable Microcapsules Containing Enzymes, Hormones, Vaccines and Other Biologicals", J. Bioeng., 1, (1976), p. 25.
Langer, "Controlled Release of Macromolecules", Chemtech., Feb. 1982, pp. 98-105.
Hutchison et al., "Biodegradable Carriers for the Sustained Release of Polypetides", TIBTECH, Apr. 1987, (vol. 5), pp. 102-106.
Chemical Abstracts, vol. 107, No. 13, abstract 109765g (1987).

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