Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Patent
1986-05-21
1987-05-05
Rose, Shep A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
424496, 424497, 514263, 514264, A61K 922, A61K 926, A61K 3152
Patent
active
046631500
ABSTRACT:
A sustained absorption theophylline-containing pellet for oral administration comprises a core of theophylline or a pharmacological equivalent thereof and an organic acid embedded in a polymeric material in a multi-layer arrangement and an outer membrane which permits release of the theophylline at a controlled rate in an aqueous medium. The pellet has a dissolution rate in vitro in an aqueous medium, which when measured in a basket assembly according to U.S. Pharmacopoeia XX at 37.degree. C. and 75 r.p.m., is not more than 15% of the total theophylline after 2 hours of measurement in a buffer solution at pH 7.5. Not more than 35% of the total theophylline is released after a total of 7 hours of measurement and not more than 65% of the total theophylline is released after a total of 13 hours.
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Geoghegan Edward J.
Panoz Donald E.
Elan Corporation P.L.C.
Falk Robert Hardy
Rose Shep A.
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