Sustained absorption pharmaceutical composition

Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form

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424496, 424497, 514263, 514264, A61K 922, A61K 926, A61K 3152

Patent

active

046631500

ABSTRACT:
A sustained absorption theophylline-containing pellet for oral administration comprises a core of theophylline or a pharmacological equivalent thereof and an organic acid embedded in a polymeric material in a multi-layer arrangement and an outer membrane which permits release of the theophylline at a controlled rate in an aqueous medium. The pellet has a dissolution rate in vitro in an aqueous medium, which when measured in a basket assembly according to U.S. Pharmacopoeia XX at 37.degree. C. and 75 r.p.m., is not more than 15% of the total theophylline after 2 hours of measurement in a buffer solution at pH 7.5. Not more than 35% of the total theophylline is released after a total of 7 hours of measurement and not more than 65% of the total theophylline is released after a total of 13 hours.

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patent: 3949068 (1976-04-01), Polin
patent: 4083949 (1978-04-01), Benedickt
patent: 4309406 (1982-01-01), Guley et al.
patent: 4324779 (1982-04-01), Dalhausen et al.
patent: 4367217 (1983-01-01), Gruber et al.
patent: 4415547 (1983-11-01), Yu et al.
patent: 4462991 (1984-07-01), Higuchi et al.

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