Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1987-01-16
1989-04-11
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424470, 514273, A61K 952, A61K 922, A61K 926, A61K 3152
Patent
active
048205214
ABSTRACT:
A sustained absorption theophylline-containing pellet for oral administration comprises a core of theophylline or a pharmacological equivalent thereof and an organic acid embedded in a polymeric material in a multi-layer arrangement and an outer membrane which permits release of the theophylline at a controlled rate in an aqueous medium. The pellet has a dissolution rate in vitro in an aqueous medium, which when measured in a basket assembly according to U.S. Pharmacopoeia XX at 37.degree. C. and 75 r.p.m., is not more than 15% of the total theophylline after 2 hours of measurement in a buffer solution at pH 7.5. Not more than 35% of the total theophylline is released after a total of 7 hours of measurement and not more than 65% of the total theophylline is released after a total of 13 hours.
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Rohm Pharma GmbH "Eudragit RL/RS".
"Pharmaceutical Dosage Forms" Edited by Liebermann and Lachman (1980), p. 434.
Geoghegan Edward J.
Panoz Donald E.
Eland Corporation P.L.C.
Rose Shep K.
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