Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2010-02-05
2011-11-08
Bausch, Sarae (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S006120, C436S063000
Reexamination Certificate
active
08053190
ABSTRACT:
Allelic variations in the genes PLEKHA1 and LOC387715 are identified herein as risk factor for Age Related Maculopathy (ARM). A method is therefore provided for identifying a risk of development of ARM in an individual that comprises identification of allelic variations in PLEKHA1 and/or LOC387715. Related apparatus, such as an array, are identified as being useful in implementing those methods.
REFERENCES:
patent: 6417342 (2002-07-01), Stone et al.
patent: 6593104 (2003-07-01), Stone et al.
patent: 7695909 (2010-04-01), Gorin et al.
patent: 2003/0017501 (2003-01-01), Hageman et al.
patent: 2003/0138798 (2003-07-01), Stone et al.
patent: 2004/0265924 (2004-12-01), Hollyfield et al.
patent: 2005/0059010 (2005-03-01), Stone et al.
Abecasis et al. (2004) Age-related macular degeneration: a high-resolution genome scan for susceptibility Loci in a population enriched for late-stage disease. Am J Hum Genet 74:482-494.
Abecasis GR, et al. (2000) MERLIN—Multipoint Engine for Rapid Likelihood Inference. Am J Hum Genet 67 (Suppl 2): 327, 50th Annual Meeting of Am Soc Hum Genet, Oct. 3-6, 2000, Abstract 1816.
Age-Related Eye Disease Study Research Group (1999) The Age-Related Eye Disease Study (AREDS): design implications. AREDS report No. 1. Control Clin Trials. 20, 573-600.
Age-Related Eye Disease Study Research Group (2000) Risk factors associated with age-related macular degeneration. A case-control . . . : AREDS Report No. 3. Ophthalmology. 107, 2224-2232.
Ayyagari, et al. (2001) Evaluation of the ELOVL4 gene in patients with age-related macular degeneration. Opthalmic Genet. 22, 233-239.
Baird, P.N., et al. (2004) The epsilon2 and epsilon4 alleles of the apolipoprotein gene are associated with age-related macular degeneration. Invest Ophthalmol Vis Sci. 45, 1311-1315.
Barrett et al. (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21:263-265.
Browning SR, et al. (2005) Case-control single-marker and haplotypic association analysis of pedigree data. Genet Epidemiol 28:110-122.
Conley, Y.P., et al. (2005) Candidate gene analysis suggests a role for fatty acid biosynthesis and regulation of the complement system in the etiology . . . Hum Mol Genet. 14, 1991-2002.
Cordell et al (2005) Genetic association studies. Lancet. 366,1121-1131.
De Luca et al. (2004) Pattern of expression of HtrA1 during mouse development. J Histochem Cytochem 2:1609-1617.
DerSimonian, R. and Laird, N. (1986) Meta-analysis in clinical trials. Control Clin Trials. 7, 177-188.
Dowler et al. (2000) Identification of pleckstrin-homology-domain-containing proteins with novel phosphoinositide-binding specificities. Biochem J 351:19-31.
Edwards et al. (2005) Complement Factor H Polymorphism and Age-Related Macular Degeneration. Science 308, 421-424.
Esparza-Gordillo et al. (2004) Genetic and environmental factors influencing the human factor H plasma levels. Immunogenetics 56:77-82.
Fan and Malik (2003) Toll-like receptor-4 (TLR4) signaling augments chemokine-induced neutrophil migration by modulating cell surface expression of chemokine receptors. Nat Med 9:315-321.
Fisher et al. (2005) Meta-analysis of genome scans of age-related macular degeneration. Hum Mol Genet. 14(15):2257-64.
Fried et al. (1991) The Cardiovascular Health Study: design and rationale. Ann Epidemiol. 1, 263-276.
Gauderman, W.J. and Morrison, J.M. (2006) QUANTO 1.1: A computer program for power and sample size calculations for genetic-epidemiology studies, http://hydra.usc.edu/gxe).
GenBank Accession No. NM—002775. NCBI Database, National Center for Biotechnology Information, NIH (Bethesda, MD, USA), Dec. 3, 2006.
GenBank Accession No. NM—002925. NCBI Database, National Center for Biotechnology Information, NIH (Bethesda, MD, USA), Nov. 18, 2006.
GenBank Accession No. NM—005308. NCBI Database, National Center for Biotechnology Information, NIH (Bethesda, MD, USA), Dec. 3, 2006.
GenBank Accession No. NM—021662. NCBI Database, National Center for Biotechnology Information, NIH (Bethesda, MD, USA), Nov. 18, 2006.
GenBank Accession No. NM—001001974. NCBI Database, National Center for Biotechnology Information, NIH (Bethesda, MD, USA), Nov. 18, 2006.
GenBank Accession No. NM—001005339. NCBI Database, National Center for Biotechnology Information, NIH (Bethesda, MD, USA), Nov. 18, 2006.
GenBank Accession No. NP—002766. NCBI Database, National Center for Biotechnology Information, NIH (Bethesda, MD, USA), Dec. 3, 2006.
GenBank Accession No. NP—005299. NCBI Database, National Center for Biotechnology Information, NIH (Bethesda, MD, USA), Dec. 3, 2006.
GenBank Accession No. NP—067635. NCBI Database, National Center for Biotechnology Information, NIH (Bethesda, MD, USA), Nov. 18, 2006.
GenBank Accession No. NP—001001974. NCBI Database, National Center for Biotechnology Information, NIH (Bethesda, MD, USA), Nov. 18, 2006.
GenBank Accession No. XM—373477. NCBI Database, National Center for Biotechnology Information, NIH (Bethesda, MD, USA), Aug. 20, 2004.
Gudbjartsson et al. (2000) Allegro, a new computer program for multipoint linkage analysis. Nat Genet 25:12-13.
Hageman and Mullins (1999) Molecular composition of drusen as related to substructural phenotype. Molecular Vision 5:28.
Hageman, G.S. et al. (2005) From the Cover: A common haplotype in the complement regulatory gene factor H (HF1/CFH) . . . Proc Natl Acad Sci U S A 102:7227-7232.
Hageman et al. (2001) An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes . . . Progress in Retinal & Eye Research 20:705-732.
Haines, J.L., et al. (2005) Complement factor H variant increases the risk of age-related macular degeneration. Science. 308, 419-421.
Haribabu and Snyderman (1993) Identification of additional members of human G-protein-coupled receptor kinase multigene family. Proc Natl Acad Sci U S A 90:9398-9402.
Hollborn et al (2004) Contrary effects of cytokines on mRNAs of cell cycle- and ECM-related proteins in hRPE cells in vitro. Curr Eye Res 28:215-223.
Howson et al. (2005) Comparison of population-and family-based methods for genetic association analysis in the presense of interacting loci. Genet Epidemiol. 29, 51-67.
Huang et al. (2004) Ignoring linkage disequilibrium among tightly linked markers induces false-positive evidence of linkage for affected sib pair analysis. Am J Hum Genet 75:1106-11.
Iyengar et al. (2004) Dissection of genomewide-scan data in extended families reveals a major locus and oligogenic susceptibility for age-related macular degeneration. Am J Hum Genet 74:20-39.
Jakobsdottir et al. (2005) Susceptibility genes for age-related maculopathy on chromosome 10q26. Am J Hum Genet. 77, 389-407.
Johnson et al. (2000) A potential role for immune complex pathogenesis in drusen formation. Experimental Eye Research 70:441-449.
Johnson LV, et al. (2001) Complement activation and inflammatory processes in Drusen formation and age related macular degeneration. Experimental Eye Research 73:887-89.
Kenealy et al. (2004) Linkage analysis for age-related macular degeneration supports a gene on chromosome 10q26. Mol Vis 10:57-61.
Klaver, C.C., et al. (1998) Genetic association of apolipoprotein E with age-related macular degeneration. Am J Hum Genet. 63, 200-206.
Klein et al. (1998) Age-related macular degeneration. Clinical features in a large family and linkage to chromosome 1q. Archives of Ophthalmology 116:1082-1088.
Klein, R., et al. (2003) Early age-related maculopathy in the cardiovascular health study. Ophthalmology. 110, 25-33.
Klein, R.J., et al. (2005) Complement factor H polymorphism in age-related macular degeneration. Science. 308, 385-389.
Kong et al. (2004) A combined linkage-physical map of the human genome. Am J Hum Genet 75:1143-1148.
Lange et al. (2001) MENDEL Version 4.0: A complete package for the exact genetic analysis of . . . Am J of Hum Genet 69 (Supplement):A1886, 51st Annual Meeting of ASHG, Abstract 1886.
Li C, et al. (2004) Assessing whether an allele can account in part for a linkage signal: the Genotype-IB
Conley Yvette P.
Ferrell Robert E.
Gorin Michael B.
Jakobsdottir Johanna
Mah-Fraser Tammy S.
Bausch Sarae
The Webb Law Firm
University of Pittsburgh—Of the Commonwealth System of Hi
LandOfFree
Susceptibility genes for age-related maculopathy (ARM) on... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Susceptibility genes for age-related maculopathy (ARM) on..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Susceptibility genes for age-related maculopathy (ARM) on... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4287848