Susceptibility gene for obesity and type II diabetes mellitus

Details Susceptibility gene for obesity and type II diabetes mellitus Susceptibility gene for obesity and type II diabetes mellitus

1995-05-19

1998-06-16

Myers, Carla J.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 912, 435810, 536 235, 536 2431, 536 2433, 436 63, 935 8, 935 9, 935 17, 935 78, C12Q 168, C12P 1934, C07H 2104

Patent

active

057668515

ABSTRACT:
The present invention provides a novel polypeptide characterized by a non-conservative missense mutation, Trp64Arg, in the .beta.3-adrenergic receptor (.beta.3AR) that increases susceptibility to obesity and non-insulin dependent diabetes mellitus (NIDDM; type II diabetes). Also provided are methods of diagnosis and methods of treatment of subjects having or at risk of having type II diabetes/obesity.

REFERENCES:
patent: 5288607 (1994-02-01), Emorine et al.
Lelias, et al., Molecular cloning of a human .beta.3-adrenergic receptor cDNA, FEBS Letters, 324(2):127, 1993.

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