Susceptibility gene for Alzheimer's disease

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C536S023100

Reexamination Certificate

active

07842455

ABSTRACT:
The invention relates to genetic screens for susceptibility to Alzheimer's disease. In particular, the invention provides genetic screens based on genotyping of the p21E2c31 polymorphism and/or the p21E3+20 C/T polymorphism in the p21cip 1 gene.

REFERENCES:
patent: WO 02/073212 (2002-09-01), None
Langdahl, Bente et al. Osteoporotic fractures are assoicated with an 86 base pair repeat polymoprhism in the interleukin 1 receptor antagonist gene but not with polymoprhisms in the interleukin 1B gene. 2000. Journal of Bone and Mineral Research. vol. 15 No. 3 pp. 402-414.
Wall, Jeffery et al. Haplotype blocks and linkage disequilbirium in the human genome. 2003. Nature Reviews Genetics. vol. 4 pp. 587-597.
Blacker, et al., “Results of a High-Resolution Genome Screen of 437 Alzheimer's Disease Families”; Human Molecular Genetics, vol. 12, No. 1, pp. 23-32 (2003).
Facher, et al., “Association Between Human Cancer and Two Polymorphisms Occuring Together in the p21Waf1/CiP1Cyclin-Dependent Kinase Inhibitor Gene”; Cancer, vol. 79, No. 12, pp. 2424-2429 ((1997).
Goodman, et al., “Evidence for Defective Retinoid Transport and Function in Late Onset Alzheimer's Disease”; Proceedings of the National Academy of Sceinces of the United States of America; vol. 100, No. 5, pp. 2901-2905 (2003).
Nagy, Zsuzsanna, “Cell Cycle Regulatory Failure in Neurones: Causes and Consequences”; Neurobiology of Aging, vol. 21, No. 6 (pp. 761-769 (2000).

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