Susceptability and resistance genes for bipolar affective...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091200, C536S023100

Reexamination Certificate

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06897022

ABSTRACT:
Chromosomal regions comprising loci associated with susceptibility and resistance to bipolar affective disorder have been identified. Methods and compositions are provided for determining the contribution of these chromosomal regions to bipolar affective disorder in an affected family, for determining in an affected family a genotype associated with increased or decreased susceptibility or resistance to bipolar illness, and for assessing an increased or decreased risk of developing bipolar illness for a tested individual from an affected family.

REFERENCES:
patent: WO 9904825 (1999-02-01), None
patent: WO 9906539 (1999-02-01), None
Strachan T., “The Human Genome”, 1992, Biosis Scientific Publishers, LTD., Oxford, England, pp. 71-96.
Stine et al., “Initial Genome Screen for Bipolar Disorder in the NIMH Genetics Initiative Pedigrees: Chromosomes 2, 11, 13, 14 and X”, American Journal of Medical Genetics (Neuropsychiatric Genetics), (1997), 74:263-269.
Rice et al., “Initial Genome Scan of the NIMH Genetics Initiative Bipolar Pedigrees: Chromosomes 1, 6, 8, 10, and 12”, American Journal of Medical Genetics (Neuropsychiatric Genetics), (1977), 74:247-253.
Blackwood et al., “A Locus for Bipolar Affective Disorder on Chromosome 4p”, Nature Genetics, vol. 12, Apr. 1996, pps. 427-430.
Berrettini, Wade, “Progress and Pitfalls: Bipolar Molecular Linkage Studies”, Affective Disorders, (1998), 50:287-297.
Ginns et al., “A Genome-Wide Search for Chromosomal Loci Linked to Mental Health Wellness in Relatives at High Risk for Bipolar Affective Disorder Among the Old Order Amish”, Proc. Natl. Acad. Sci., vol. 25, pp. 15531-15536.

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