Surgical method

Details Surgical method Surgical method

1995-03-21

1997-10-28

Leary, Louise

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514912, 514913, 514954, 435101, 424422, 424423, 424427, 536124, 5361231, A01N 4304, A61K 31715, A61F 1300, A61F 200

Patent

active

056818254

ABSTRACT:
Methods of facilitating surgical operations that involve the eye or eye area comprise introducing an opthalmologically acceptable composition containing hyaluronic acid into the site of the surgical operation. The hyaluronic acid comprises a chemically unmodified sterilized hyaluronic acid substance having a weight average molecular weight of from 4,500,000 to 12,000,000 daltons, a zero shear viscosity of from 1,000 to 80,000 Pas as measured on a 1.3-1.6% (wv) solution of hyaluronic acid substance in physiological phosphate buffer, and an absorbance at 257 nm of less than 3.5 when measured on a 1% solution of hyaluronic acid substance in sodium chloride buffer in a 10 mm cuvette. Preferred sterilized solutions of hyaluronic acid comprise hyaluronic acid which is chemically unmodified from the naturally occurring hyaluronic acid and has a weight average molecular weight of from 4,500,000 to 8,000,000 daltons, a zero shear viscosity of from 1,000 to 20,000 Pas and an absorbance at 257 nm of less than 3.5.

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Obstbaum; "Ocular Surgery News"; vol. 8(12), p. 706-712, Jun. 15, 1990.
"The Scope of Hyaluronic Acid as an Experimental Intraocular Implant", Erwin Hultsch, Ophthalamology, vol. 87, No. 7, Jul. 1990, pp. 706-712.

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