Surgery – Means for introducing or removing material from body for... – Material introduced into and removed from body through...
Patent
1996-06-26
1998-10-13
Mendez, Manuel
Surgery
Means for introducing or removing material from body for...
Material introduced into and removed from body through...
6048901, A61M 3100
Patent
active
058205837
ABSTRACT:
A method and solution for perioperatively inhibiting a variety of pain and inflammation processes at wounds from general surgical procedures including oral/dental procedures. The solution preferably includes multiple pain and inflammation inhibitory at dilute concentration in a physiologic carrier, such as saline or lactated Ringer's solution. The solution is applied by continuous irrigation of a wound during a surgical procedure for preemptive inhibition of pain and while avoiding undesirable side effects associated with oral, intramuscular, subcutaneous or intravenous application of larger doses of the agents. One preferred solution to inhibit pain and inflammation includes a serotonin.sub.2 antagonist, a serotonin.sub.3 antagonist, a histamine antagonist, a serotonin agonist, a cyclooxygenase inhibitor, a neurokinin.sub.1 antagonist, a neurokinin.sub.2 antagonist, a purinoceptor antagonist, an ATP-sensitive potassium channel opener, a calcium channel antagonist, a bradykinin.sub.1 antagonist, a bradykinin.sub.2 antagonist and a .mu.-opioid agonist.
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Demopulos Gregory A.
Herz Jeffrey M.
Pierce Pamela A.
Mendez Manuel
Omeros Medical Systems, Inc.
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