Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Two or more cell types – per se – in co-culture
Reexamination Certificate
2002-03-06
2010-06-22
Wehbe, Ann Marie S (Department: 1633)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Two or more cell types, per se, in co-culture
C435S397000, C435S373000, C424S093100
Reexamination Certificate
active
07741116
ABSTRACT:
A device, and method of making the device, capable of therapeutic treatment and/or for in vitro testing of human skin. The device may be used on skin wounds for burned, injured, or diseased skin, and provides structures and functions as in normal uninjured skin, such as barrier function, which is a definitive property of normal skin. The device contains cultured dermal and epidermal cells on a biocompatible, biodegradable reticulated matrix. All or part of the cells may be autologous, from the recipient of the cultured skin device, which advantageously eliminates concerns of tissue compatibility. The cells may also be modified genetically to provide one or more factors to facilitate healing of the engrafted skin replacement, such as an angiogenic factor to stimulate growth of blood vessels. The inventive device is easy to handle and manipulate for surgical transplant, can be made into large sheets to minimize the number of grafts required to cover a large surface area to be treated, and can be produced within the time frame to treat a burned individual requiring a skin graft.
REFERENCES:
patent: 4458678 (1984-07-01), Yannas et al.
patent: 4673649 (1987-06-01), Boyce et al.
patent: 4963489 (1990-10-01), Naughton et al.
patent: 5273900 (1993-12-01), Boyce
patent: 5443950 (1995-08-01), Naughton et al.
patent: 5536656 (1996-07-01), Kemp et al.
patent: 5755814 (1998-05-01), Berg et al.
patent: 5785964 (1998-07-01), Naughton et al.
patent: 5858721 (1999-01-01), Naughton et al.
patent: 5976878 (1999-11-01), Boyce
patent: 6039760 (2000-03-01), Eisenberg
patent: 2002/0193875 (2002-12-01), Amano et al.
patent: 1363398 (2002-08-01), None
patent: 0363400 (1993-03-01), None
patent: 05-317406 (1993-12-01), None
patent: 2000-125855 (2000-05-01), None
patent: WO 91/16010 (1991-10-01), None
patent: WO 95/19743 (1995-07-01), None
patent: WO 97 41298 (1997-10-01), None
patent: WO 97/41208 (1997-11-01), None
patent: WO 98/22154 (1998-05-01), None
patent: WO 99/43787 (1999-09-01), None
patent: WO 99/45770 (1999-09-01), None
patent: WO 01/92477 (2001-12-01), None
Wilkins et al Biotech. and Bioeng. 43:747-756, 1994.
Supp et al. The FASEB Journal. 16:797-804, 2002.
Naughton, Ann. N.Y. Acad Sci. 961:372-385, 2002.
Niels et al, J Invest Dermol 97(5):843-848, 1991.
Boyce, “Skin repair with cultured cells and biopolymers.” Chapter 15; in:Human Biomaterials Applications, Wise et al. Eds., Humana Press Inc., New Jersey, 1996, 347-377.
Boyce et al.,Structure of a collagen-GAG dermal skin substitute optimized for cultured human epidermal keratinocytes., Journal of Biomedical Materials Research, vol. 22, 1988, 939-957.
Boyce et al.,Reconstructed skin from cultured human keratinocytes and fibroblasts on a collagen-glycosaminoglycan biopolymer substrate, Skin Pharmacology 1990, 3:136-143.
Boyce,Cultured skin substitutes: A Review., Tissue Engineering, vol. 2., No. 4, 1996, 225-266.
Harriger et al.,Glutaraldehyde crosslinking of collagen substrates inhibits degradation in skin substitutes grafted to athymic mice., Journal of Biomedical Materials Research, vol. 35, 1997, 137-145.
Boyce,Cultured skin for wound closure., Skin Substitute Production by Tissue Engineering: Clinical and Fundamental Applications, M. Rouabhia Ed., Texas, 1997, 75-102.
Boyce,Skin substitutes from cultured cells and collagen-GAG polymers., Medical & Biological Engineering & Computing, 1998, 791-800.
Dagalakis et al.,Design of an artificial skin. Part III. Control of pore structure., Journal of Biomedical Materials Research, vol. 14, 1980, 511-528.
Yannas et al.,Design of an artificial skin. II. Control of chemical composition., Journal of Biomedical Materials Research, vol. 14, 1980, 107-131.
Yannas et al.,Design of an artificial skin. I. Basic design principles., Journal of Biomedical Materials Research, vol. 14, 1980, 65-81.
Partial European Search Report, EP09004333, Date search completed May 12, 2009, Date mailed May 25, 2009, 9 pages.
Boyce, Steven T., Design principles for composition and performance of cultured skin substitutes, Burns 27 (2001) 523-533.
Boyce, Steven T. et al.,Pigmentation and Inhibition of Wound Contraction by Cultured Skin Substitutes with Adult Melanocytes after Transplantation to Athymic Mice, Journal of Investigative Dermatology, vol. 100, No. 4, Apr. 1993, pp. 360-365.
Boyce, Steven T.,Design Principles for Composition and Performance of Cultured Skin Subsitutes, Burns 27 (2001) 523-533.
PCT Examiner,International Search Report, Application No. PCT/US03/O6584, mailed on Nov. 9, 2003.
Shriners Hospitals For Childrens
Thompson Hine LLP
University of Cincinnati
Wehbe Ann Marie S
LandOfFree
Surgical device for skin therapy or testing does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Surgical device for skin therapy or testing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Surgical device for skin therapy or testing will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4205953