Surfactants as malarial chloroguine resistance reversal agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S718000, C514S723000, C514S560000

Reexamination Certificate

active

10148498

ABSTRACT:
According to the first aspect of the invention, a composition for reversing malarial resistance to quinolines is disclosed. The composition includes a surfactant, such as nonylphenolethoxylate (NPE) in an admixture with a pharmaceutically acceptable carrier, excipient, or diluent. According to a second aspect of the invention, a composition for the prevention or treatment of malaria is provided. The composition comprises a pharmaceutically effective amount of a quinoline in combination with a surfactant, such as NPE, for reversing malarial resistance to quinolines. According to a third aspect of the invention, a method of preventing or treating malaria in a person is provided. The method comprises administering to a patient in need thereof one or both of the compositions described above.

REFERENCES:
patent: 5741525 (1998-04-01), Larsen
patent: 5776891 (1998-07-01), Coon et al.
patent: 6045786 (2000-04-01), Cone et al.
Merck Index 10thedition, windholz et al Eds. Merck & Co., Rathway N.J. 1983, abstract #6518.
White et al. “The Treatment of Malaria” 1996, The New England Journal of Medicine, 335(11), 800-6.
Intestinal Permeability Enhancement: Structure-Activity and Structure-Toxicity Relationships for Nonylphenoxypolyoxyethylene Surfactant Permeability Enhancers. Pharmaceutical Research, vol. 11, No. 10, pp. 1501-1504, 1994.
Crandall, Ian et al. (2000). Nonylphenolethoxylates as Malarial Chloroquine Resistance Reversal Agents.Antimirobial Agents and Chemotherapy44:9 (2431-2434).
International Search Report, Oct. 15, 2001.

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