Surfactant-stabilized microbubble mixtures, process for preparin

Details Surfactant-stabilized microbubble mixtures, process for preparin Surfactant-stabilized microbubble mixtures, process for preparin

1993-11-22

1994-10-04

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

12866002, A61K 4900

Patent

active

053524365

ABSTRACT:
The present invention is a mixture including a solvent, a first surfactant and a second, dispersible surfactant different from the first surfactant, the mixture having stabilized gas microbubbles formed therein by sonication. The gas microbubbles are useful in ultrasonic diagnostics. Preferably the first surfactant is substantially soluble in the solvent and the second surfactant is substantially insoluble in the solvent. The present invention also includes a process for preparing the stabilized gas microbubbles and a method for altering the contrast of an ultrasonic image using the microbubbles as a contrast agent.

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patent: 4957656 (1990-09-01), Cerny et al.
H. J. Bleeker, K. K. Shung and J. L. Barnhart, "Ultrasonic Characterization of Albunex.RTM., a New Contrast Agent," J. Acoust. Soc. Am. 87(4), Apr. 1990, pp. 1792-1797.
N. Nanda (E. D.), "Advances in EchoContrast Enhancement," Advances in EchoContrast (Aims and Scope), 1989.

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