Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2007-02-20
2007-02-20
Kerr, Kathleen M. (Department: 1656)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S013800, C514S014800, C514S015800, C514S016700, C530S300000, C530S324000, C530S326000
Reexamination Certificate
active
10192832
ABSTRACT:
This work describes a new class of short polypeptides that can self-assemble to form regular nanotubes with an average diameters of about 50 nm. These peptides (7 to 8 amino acids) have a structure very similar to those observed in surfactant molecules with a defined hydrophilic head group constituting of charged amino acids and a lipophilic tail made out of hydrophobic amino acids such as alanine, valine or leucine. Cryo-TEM micrographs show numerous three-fold junctions connecting the self-assembling nanostructures and thus leading to the formation of a rather dense network of entangled nanotubes. Additionally, the observation of clear openings at the end of the supramolecular structures confirms the presence of tubular organization.
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International Search Report Completed on Aug. 28, 2002 and Mailed on Sep. 19, 2002.
Vauthey Sylvain
Zhang Shuguang
Foley & Hoag LLP
Gordon Dana M.
Kerr Kathleen M.
Liu Samuel W.
Massachusetts Institute of Technology
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