Surfactant inhibition of dental plaque

Details Surfactant inhibition of dental plaque Surfactant inhibition of dental plaque

1988-01-14

1989-05-09

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Dentifrices

Fluorine or fluorine compound containing

424 49, A61K 716, A61K 718

Patent

active

048288497

ABSTRACT:
The invention provides an oral preparation or composition such as a mouthwash, mouthrinse, toothpaste and the like containing certain classes of surfactants which act to inhibit plaque formation by inhibiting the initial adherence of bacteria to the dentin surfaces and in the case of one class of surfactants additionally inhibiting the glucosyl transferase catalysis to prevent the synthesis of extracellular polysaccharides from sucrose.
The surfactants comprise substituted taurines, substituted isethionates and substituted hydroxy sultaines in which the substituents are long chain hydrocarbon radicals. The surfactants are employed in the aqueous-based oral compositions at concentrations between about 0.00001M to 0.1M to effect inhibition.

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patent: 3937807 (1976-02-01), Haefele
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patent: 4051234 (1977-09-01), Gieske
patent: 4067962 (1978-01-01), Juneja
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patent: 4205061 (1986-05-01), Vidra
patent: 4416867 (1983-11-01), Ritchey
patent: 4425325 (1984-01-01), Ritchey
patent: 4428928 (1984-01-01), Muhler
patent: 4627452 (1987-03-01), Ritchey

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