Surfactant and pharmaceutical compositions containing same

Details Surfactant and pharmaceutical compositions containing same Surfactant and pharmaceutical compositions containing same

1984-02-27

1986-07-29

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 2, 514975, 260403, A61K 31685, C07F 902

Patent

active

046031243

ABSTRACT:
A surfactant having the capacity of reducing the surface tension in pulmonary alveoli significantly is provided. The surfactant consists essentially of, based on the total weight of the surfactant, 50.6-85.0% of a chlorine phosphogylceride, 4.5-37.6% of an acid phospholipid, 4.6-24.6% of a fatty acid or its analogue and 0.1-10.0% of a lipoprotein derived from the lung of a mammal. These components cooperate to form a kind of film at a gas-liquid interface within pulmonary alveoli and reduce the surface tension. A pharmaceutical composition comprising the surfactant is useable for the clinical treatment of respiratory distress syndrome.

REFERENCES:
patent: 4312860 (1982-01-01), Clements
patent: 4338301 (1982-07-01), Tetsuro et al.
Suzuki, Journ. Lipid Research, vol. 23, pp. 62-69 (1982) (Corresponding to Chem. Abstract 96:99813j (1982)).
Suzuki et al., Exp'l Studies on the Pulmonary Surfactant, Reconstitution of Surface-Active Material, Chem. Abstracts 96:99812h (1982).
Kokubo et al., Trial Preparations of Artificial Surfactant, Effect on Lung Lavaged Rabbits, Chem. Abstracts 99:82279d (1983).
Suzuki et al., Investigation on the Surface Activity of Lipid-Protein Complexes Reconstituted from Phospholipids and Surfactant Apoprotein, Chem. Abs. 99:66246k (1983).
King et al., Surface Active Materials from Dog Lung, II, (Composition . . . , Chem. Abstracts 77:162283m (1972a).
King et al., Surface-Active Materials from Dog Lung, I, Method of Isolation, Chem. Abstracts 77:123604x (1972b).
Henderson et al., . . . Pulmonary Surfactant Lipid Removed from the Lung of Beagle Dogs by Lavage, Chem. Abstracts 81:148063r (1974).
Guerrero et al., Interference of Free Fatty Acids on Pulmonary Surfactant in the Rabbit, Chem. Abstracts 97:214807v (1982).

Affiliated with

Also associated with

Rating

Surfactant and pharmaceutical compositions containing same does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Surfactant and pharmaceutical compositions containing same, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Surfactant and pharmaceutical compositions containing same will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-699941