Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals
Reexamination Certificate
2007-06-12
2007-06-12
Chin, Christopher L. (Department: 1641)
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
C385S012000, C385S129000, C385S130000, C385S131000, C422S082050, C422S082110, C435S287100, C435S287200, C435S288700, C435S808000, C436S525000, C436S528000, C436S529000, C436S531000, C436S805000
Reexamination Certificate
active
10415306
ABSTRACT:
The object with the funtionalized hydrogel surface for detection of analyte molecules is obtainable by a process including (1) providing a hydrogel layer on a base surface; (2) bonding organic molecules to the hydrogel layer, each including a chain of atoms with a chain length of at least 8 atoms and a terminal group, which is an amine group, a carboxylic acid group, or a derivative thereof, and (3) reacting the terminal group with a receptor molecule that contains at least three groups, each of which is an amine group, a carboxylic acid group, a sulfonic acid group, a phosphoric acid group, a phosphonic acid group, or a derivative thereof. The receptor molecule can be a protein and the hydrogel can include a water-swellable organic polymer. A method of detecting analyte molecules, for example by surface resonance spectroscopy, is also part of the invention.
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Chin Christopher L.
Hofmann Andreas
Striker Michael J.
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