Drug – bio-affecting and body treating compositions – Immunoglobulin – antiserum – antibody – or antibody fragment,... – Binds antigen or epitope whose amino acid sequence is...
Reexamination Certificate
2007-03-27
2007-03-27
Campell, Bruce R. (Department: 1645)
Drug, bio-affecting and body treating compositions
Immunoglobulin, antiserum, antibody, or antibody fragment,...
Binds antigen or epitope whose amino acid sequence is...
C424S130100, C424S141100, C424S143100, C424S150100, C424S163100, C424S164100, C424S165100, C424S178100, C424S278100, C424S139100, C530S387100
Reexamination Certificate
active
10911507
ABSTRACT:
Isolated peptide sequences and proteins containing these sequences are provided which are useful in the prevention and treatment of infection caused by Gram-positive bacteria. The peptide sequences have been shown to be highly conserved motifs in the surface proteins of Gram-positive bacteria, and these consensus sequences include amino acid sequences such as LPXTG (SEQ ID NO:13), ALKTGKIDIIISGMTSTPERKK (SEQ ID NO:14), VEGAVVEKPVAEAYLKQN (SEQ ID NO:15), and EYAGVDIDLAKKIAK (SEQ ID NO:16). By virtue of the highly conserved regions, the sequences and the proteins including these sequences can be utilized to generate antibodies which can recognize these highly conserved motifs and the proteins containing them and thus be useful in the treatment or prevention of a wide range of infections caused by Gram-positive bacteria.
REFERENCES:
patent: WO 98/01154 (1998-01-01), None
Burnie et al. 2000. Infect and Immun. vol. 68(6): 3200-3209.
Ala′ Aldeen et al., “Unveiling of genetic basis of resistance of S aureus to antibiotics”, The Lancet, vol. 357, No. 9264, Apr. 21, 2001, pp. 1218-1219.
Navarre et al., “Surface Proteins of Gram-Positive Bacteria and Mechanisms of Their Targeting to the Cell Wall Envelope”, Microbiology and Molecular Biology Reviews, Mar. 1999, vol. 63, No. 1, pp. 174-229.
Novick, “Sortase: the surface protein anchoring transpeptidase and the LPXTG motif”, Trends in Microbiology, vol. 8, No. 4, Apr. 2000, pp. 148-151.
Database EPO Proteins Online, “Sequence 4716 from Patent WO02094868”, XP-002319382, Feb. 20, 2003.
Hook Magnus A. O.
Xu Yi
Campell Bruce R.
Hines J.
Schulman B. Aaron
Stites & Harbison PLLC
The Texas A & M Univerisity System
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