Surface proteins from coagulase-negative staphylococci and...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...

Reexamination Certificate

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C514S012200

Reexamination Certificate

active

07968100

ABSTRACT:
Surface proteins are provided which generate polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positivestaphylococcusbacteria, such asS. aureusand to coagulase-negative bacteria, such asS. epidermidisandS. hemolyticus. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common betweenS. aureusand coagulase-negative staphylococci, or the A domains of those surface proteins, and these recombinant surface proteins are used to generate the cross-reactive antibodies. Vaccines comprising an immunologically effective amount of the proteins are also provided, and these vaccines are used in methods for the treatment or protection against a wide variety of staphylococcal infections.

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