Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Amino acid sequence disclosed in whole or in part; or...
Reexamination Certificate
2011-06-28
2011-06-28
Zeman, Robert A (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Amino acid sequence disclosed in whole or in part; or...
C514S012200
Reexamination Certificate
active
07968100
ABSTRACT:
Surface proteins are provided which generate polyclonal and monoclonal antibodies which are cross-reactive to both coagulase-positivestaphylococcusbacteria, such asS. aureusand to coagulase-negative bacteria, such asS. epidermidisandS. hemolyticus. The antibodies may be generated from surface proteins that have been isolated on the basis of characteristics that may be common betweenS. aureusand coagulase-negative staphylococci, or the A domains of those surface proteins, and these recombinant surface proteins are used to generate the cross-reactive antibodies. Vaccines comprising an immunologically effective amount of the proteins are also provided, and these vaccines are used in methods for the treatment or protection against a wide variety of staphylococcal infections.
Foster Timothy
Hutchins Jeff T.
Pallen Mark
Patti Joseph M.
Roche Fiona
Inhibitex, Inc.
Provost Fellows and Scholars of the College of the Holy and Undi
Schulman, Esq. B. Aaron
Stites & Harbison PLLC
Universita'Degli Studi Di Pavia
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