Chemical apparatus and process disinfecting – deodorizing – preser – Analyzer – structured indicator – or manipulative laboratory... – Means for analyzing liquid or solid sample
Patent
1989-05-10
1991-07-30
Warden, Robert J.
Chemical apparatus and process disinfecting, deodorizing, preser
Analyzer, structured indicator, or manipulative laboratory...
Means for analyzing liquid or solid sample
422 681, 422 8209, 356318, 356445, 436515, 436516, G01N 2100, G01N 2155, G01N 33559, G01J 330
Patent
active
050358634
ABSTRACT:
A surface plasmon resonance (SPR) sensor is adapted for biochemical and similar testing on large area samples such as the gel of an electrophoresis apparatus. The gel is sandwiched between a pair of plates. One of the plates is of transparent material and, sandwiched between itself and the gel is a metal layer of a mosaic of silver dots. Light from a source is directed via a reflector and undergoes total internal reflection at the interfacce between the transparent plate and metal layer. The reflected light is passed via another reflector to a light detector. The equipment is arranged so that SPR occurs at the metal layer, which resonance is critically dependent upon the refractive index of the gel. The structure including the light source and detector, together with reflectors is caused to scan across the gel surface to enable a two-dimensional representation of the changes in refractive index across the gel to be built up. This enables the progress of sequencing to be monitored.
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Brady Michael A. W.
Finlan Martin F.
Amersham International plc
Trembley Theresa A.
Warden Robert J.
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