Surface plasmon resonance microscope using common-path...

Details Surface plasmon resonance microscope using common-path... Surface plasmon resonance microscope using common-path...

2005-11-29

2008-03-04

Connolly, Patrick (Department: 2877)

Optics: measuring and testing

By light interference

Having polarization

Reexamination Certificate

active

07339681

ABSTRACT:
The present invention integrates the surface plasmon resonance and common-path phase-shift interferometry techniques to develop a microscope for measuring the two-dimensional spatial phase variation caused by biomolecular interactions on a sensing chip without the need for additional labeling. The common-path phase-shift interferometry technique has the advantage of long-term stability, even when subjected to external disturbances. Hence, the developed microscope meets the requirements of the real-time kinetic studies involved in biomolecular interaction analysis. The surface plasmon resonance microscope of the present invention using common-path phase-shift interferometry demonstrates a detection limit of 2×10−7refractive index change, a long-term phase stability of 2.5×10−4π rms over four hours, and a spatial phase resolution of 10−3π with a lateral resolution of 100 μm.

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