Surface plasmon resonance biosensor for measurement of...

Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals

Reexamination Certificate

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C436S513000, C436S524000, C436S525000, C436S530000, C436S063000, C436S164000, C436S805000, C422S082050, C422S082110

Reexamination Certificate

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07074621

ABSTRACT:
The present invention provides a method of detecting human antibodies in a sera solution. The invention also provides a method of quantitating anti-glycolipid antibody levels in solutions. The invention provides a method of diagnosing disease states, including neurological diseases, by quantitating a subject's antibody levels.

REFERENCES:
patent: 5436161 (1995-07-01), Bergstrom et al.
patent: 5985578 (1999-11-01), Pestronk
patent: WO 9011525 (1990-10-01), None
Catimel, B et al., (1998) Direct immobilization of gangliosides onto gold-carboxymethyldextran sensor surfaces by hydrophobic interaction: applications to antibody characterization,Glycobiology8: 927-938.
Harrison, Blair A et al. (1997) A kinetics approach to the characterization of an IgM specific for the glycolipid asialo-GMl,Journal of Immunological Methods212: 29-39.
Malmqvist M. Biacore: an affinity biosensor system for characterization of biomolecular interactions. Biochem Soc Trans 1999; 27:335-340; and.
Fagerstam LG, Forstell-Karlsson A, Karlsson R, Presson B, Ronberg I. Biospecific interaction analysis using surface plasmon reasonance detection applied to kinetic, binding site and concentration analysis. J Chromatography 1992; 597: 397-410.
U.S. Appl. No. 09/825,572, filed Apr. 3, 2001.

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