Surface-modifying copolymers having cell adhesion properties

Details Surface-modifying copolymers having cell adhesion properties Surface-modifying copolymers having cell adhesion properties

1995-06-07

1998-03-31

Sergent, Rabon

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

424 7817, 424 7818, 424 7827, 424 7831, 424 7835, 424 7837, 514 2, 524 17, 524 20, 524188, 524261, 524262, 524265, 524267, 524269, 524498, 524499, 524506, 524507, 524515, 524577, 524588, 524589, 524590, 525541, 525 5411, 525 88, 525 90, 525 92R, 525 92A, 525 92C, 525 92G, 525 96, 525 95, 525100, 525101, 525102, 525106, 525123, 525130, 525217, 525231, 525241, 525452, 525453, 525455, 525457, 5262381, 526279, 526346, 528 10, 528 44, 528 25, 528 28, 528 85, 527200, 527201, 527203, 527204, 530300, 530345, A61K

Patent

active

057335389

ABSTRACT:
A hemocompatible surface-modifying additive is provided for modifying polyurethane or polyurethane urea substrates. The additive has a polyurethane or polyurethane urea hard block or an alternative block which is miscible with the poly(urethane) or poly(urethane-urea) base polymer, a polysiloxane hydrophobic soft block, an optional hydrophilic spacer and a peptide selected from the group consisting of Arg-Gly-Asp, X-Arg-Gly-Asp, Arg-Gly-Asp-X and X-Arg-Gly-Asp-X', wherein X and X' are amino acids.

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J.A. Hubbell et al., Surface-grafted Cell-binding Peptides in Tissue Engineering of the Vascular Graft, Annals of the NY Academy of Sciences, 665:253-258 (1992).

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